Tapentadol advantages Tapentadol is a drug that is often used to treat mild to severe pain. This medicine is called Nucynta, and it is an opiate painkiller. If you take it by mouth, it starts working in less than an hour. There are two kinds of Tapentadol: ones that work right away and ones that take longer. Most of the time, Tapentadol ER is given to people who need pain relief 24 hours a day,...