Creative Biostructure, a biotechnology company that offers dedicated services aimed to determine the structure of biomolecules, now provides advanced structural biology platform and extensive expertise for scientists from academic institutions and the pharmaceutical industry, making the integration of structural information faster.

Currently, scientists are working to map the dynamics of systems made up of hundreds of biomacromolecules, including how these systems assemble, disassemble, function, and are regulated by interactions with other systems. The methods of structural biology must be integrated because conventional approaches to structure determination may not be sufficient. Integrative approaches bring together data from various sources at once to create a shared understanding of a system.

Now mainstream structural determination techniques including x-ray crystallography, NMR spectroscopy and cryo-electron microscopy, as well as novel structural techniques are available at Creative Biostructure. Scientists at the company are trying to combine those techniques with cellular biological approaches to help researchers access structural data that is dynamic at the cellular level.

Featured integrative structural biology services at Creative Biostructure

Model Reconstruction of Crystal Structures Using Cryo-EM and NMR

Cryo-EM is used in this method to determine a low-resolution structure that is then used as the initial searching model for NMR spectroscopy or X-ray crystallography. Theoretical phases can be calculated after phasing the high-resolution X-ray data with low-resolution cryo EM reconstruction by molecular replacement. It has been demonstrated that this technique is effective in figuring out the structures of a number of large complexes, including ribosomes and viruses.

Combinational Applications of Cryo-EM, X-ray Crystallography and NMR

Researchers can better study scientific questions by processing in-depth analyses of the dynamic macromolecular machinery in a variety of organisms thanks to the combination of multiple technologies, such as X-ray crystallography, cryo-EM, and NMR spectroscopy.

Combinational Applications of Cryo-EM and Mass Spectrometry

Particular promising for the study of the topology and structure of large biomolecular machines. Ribosomes, proteasomes, chromatin remodelers, polymerases, and photosystem complexes are some of the targets that have been studied so far.

“The integrated structural biology approaches can fill in the gaps left by individual structural technologies and provide a framework for combining information from various structural approaches to create a more comprehensive picture of dynamic biological assemblies.” Commented Joanna, the chief marketing staff at Creative Biostructure.

To know more about the Integrative Structural Biology Services offered by Creative Biostructure, please visit https://www.creative-biostructure.com/integrative-structural-biology-services.htm.