Describe tapentadol Tapentadol is a benzenoid opioid analgesic that is sold under the brand names Nucynta and others. It works in two ways: as an agonist of the -opioid receptor and as a block of norepinephrine reuptake. After taking it by mouth, the pain relief starts in 32 minutes and lasts for 4–6 hours. Nucynta ER, which is an extended-release form of tapentadol, is used to treat pain...